According to IU Research Technology Manager of Campus Bridging and Research Infrastructure Rich Knepper, living cyberinfrastructure implies a close link between technology and scientific outcomes. Science becomes part of the technology that supports it. In a talk at the International Conference on Infrastructures and Cooperation in E-science and E-humanities, Leipzig, Germany, in June 2014 titled “Living cyberinfrastructures and their impact on scientific research,” Knepper explored the evolving model of center-based cyberinfrastructure and some of the challenges that attend that model. Computation centers like XSEDE are alternatives to declining single-scientist resources.  But there are trade-offs.  In exchange for the free cycles they provide, scientists may need to agree to center requirements or adapt their software, which may curb experimentation. Watch the presentation on YouTube at https://www.youtube.com/watch?v=LQygr2p-EPM.