Using supercomputing resources provided by the National Science Foundation’s Blue Waters and XSEDE projects and the Department of Energy’s INCITE program, a team of researchers has performed the most precise calculation to date of a key quantity in high-energy physics, a field that asks fundamental questions about the nature of matter and our universe. This work on the ratio of the leptonic decay constants of the K and pi mesons was recently published in Physical Review Letters. To read further, please visit http://www.ncsa.illinois.edu/News/Stories/MesonMission/.